CALL FOR PAPERS Renal Hemodynamics A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren
نویسندگان
چکیده
Wen-Pyng Wu, Chi-Hao Chang, Yung-Tsung Chiu, Cheng-Lung Ku, Mei-Chin Wen, Kuo-Hsiung Shu, and Ming-Ju Wu Graduate Institute of Clinical Medical Science, China Medical University; Division of Nephrology, Chang-Bing Show Chwan Memorial Hospital; Institute of Clinical Medicine, National Yang Ming University; Departments of Research, Pathology, and Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital; Chung-Shan Medical University; and Graduate Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan
منابع مشابه
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren.
The protective effect of combination therapy with valsartan and aliskiren against renal fibrosis remains to be defined. This study was undertaken to examine the protective effects of the combination of valsartan and aliskiren against renal fibrosis induced by unilateral ureteral obstruction (UUO). Combination therapy with valsartan (15 mg·kg(-1)·day(-1)) and aliskiren (10 mg·kg(-1)·day(-1)), va...
متن کاملRenin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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Introduction & Objective: Comparative reductase inhibitors, such as simvastatin increase HDL-cholestrol and decrease serum triglyceride and cholesterol. It is widely recognized that statins have organ protective nature and most effective for organ damage progressing. Obstructive uropathy can be used to indicate any obstruction to urinary flow which causes a developing of hydronephrosis, tubul...
متن کاملCombination Therapy with Losartan and α-Tocopherol in Acute Ureteral Obstruction-Induced Renal Excretory Dysfunction and Acidification Defect
Background: Previous study by the authors showed that a-tocopherol prevents oxidative stress but would not improve depressed excretory variables in post-obstructed kidney (POK) after release of 24-h unilateral ureteral obstruction (UUO). This study is a supplementary investigation on the effects of a-tocopherol combined with an antagonist of angiotensin-II type-1 (AT1) receptor on renal dysfunc...
متن کاملTreatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin
The aim of this study was to assess any potential additive effects of a treatment combining aliskiren with paricalcitol on reducing renal fibrosis. C57BL/6J mice were treated individually with aliskiren and/or paricalcitol until 7 days after initiation of unilateral ureteral obstruction (UUO).In obstructed kidneys of UUO mice, monotherapy with aliskiren or paricalcitol significantly attenuated ...
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